Truth and knowledge aren't going to come to anyone through prayer, meditation, or any kind of internal conversation. Even conversing with another person will just lead you to taste a different flavor of bullshit.
Truths can only be wrested from nature through repetitive experimentation. If you want to actually gain any real knowledge, pursue one of the hard sciences. Discover something no person has ever known before, and contribute meaningfully to the sum total of human knowledge.
There is no ultimate answer to life, the universe, and everything. It's all baby steps that have gotten us to the moon, landed robots on mars, and will one day allow us to reach the stars.